肖建球，男，1985年1月出生，江西吉水人。2008年于沈阳农业大学生物科学与技术学院生物技术专业获学士学位。2014年于复旦大学生命科学学院获遗传学博士学位。2015年起至今分别在美国杜克大学和圣路易斯华盛顿大学做博士后研究。博士期间研究方向为医学遗传学，主要利用比较基因组杂交技术 （CGH array）和二代测序技术（next generation sequencing）对遗传样本进行高通量高精度分析筛查致病基因，并进行后续的生化功能分析。博士后工作则利用CRISPR-Cas9技术构建老鼠模型，从体内和体外实验入手，对炎症产生机制及破骨细胞分化机制进行深入研究。目前已在New England Journal of Medicine,Nature,PLoS Biology,Human Molecular Genetics等杂志发表SCI论文12篇。
代表性论文和成果：
* co-first author
1.Xiao J*, Zhang L*, Wang J, Jiang Y, Jin L, Lu J, Jin L, Zhong C, Xu X, Zhang F (2014) Rearrangement structure-independent strategy of CNV breakpoint analysis.Molecular Genetics and Genomics289:755–763.
2.Zhao N*, Xiao J*, Zheng Z*, Fei G, Zhang F, Jin L, Zhong C (2015) Single nucleotide polymorphisms and haplotypes of non-coding area in theCPgene correlated with Parkinson’s disease.Neuroscience Bulletin31(2):245-56.
3.Wu N*, Ming X*, Xiao J*, Wu Z*, Chen X*, Shinawi M, Shen Y, Yu G, Liu J, Xie H, Gucev ZS, Liu S, Yang N, Al-Kateb H, Chen J, Zhang J, Hauser N, Zhang T, Tasic V, Liu P, Su X, Pan X, Liu C, Wang L, Shen J, Shen J, Chen Y, Zhang T, Zhang J, Choy KW, Wang J, Wang Q, Li S, Zhou W, Guo J, Wang Y, Zhang C, Zhao H, An Y, Zhao Y, Wang J, Liu Z, Zuo Y, Tian Y, Weng X, Sutton VR, Wang H, Ming Y, Kulkarni S, Zhong TP, Giampietro PF, Dunwoodie SL, Cheung SW, Zhang X, Jin L, Lupski JR, Qiu G, Zhang F. (2015)TBX6Null Variants and a Common Hypomorphic Allele in Congenital Scoliosis.New England Journal of Medicine372(4):341-50.
4.Liu Z, Li X, Zhang JT, Cai YJ, Cheng TL, Cheng C, Wang Y, Zhang CC, Nie YH, Chen ZF, Bian WJ, Zhang L, Xiao J, Lu B, Zhang YF, Zhang XD, Sang X, Wu JJ, Xu X, Xiong ZQ, Zhang F, Yu X, Gong N, Zhou WH, Sun Q, Qiu Z. (2016) Autism-like behaviours and germline transmission in transgenic monkeys overexpressing MeCP2.Nature530(7588):98-102
5.Fromer M, Roussos P, Sieberts SK, Johnson JS, Kavanagh DH, Perumal TM, Ruderfer DM, Oh EC, Topol A, Shah HR, Klei LL, Kramer R, Pinto D, GümüşZH, Cicek AE, Dang KK, Browne A, Lu C, Xie L, Readhead B, Stahl EA, Xiao J, Parvizi M, Hamamsy T, Fullard JF, Wang YC, Mahajan MC, Derry JM, Dudley JT, Hemby SE, Logsdon BA, Talbot K, Raj T, Bennett DA, De Jager PL, Zhu J, Zhang B, Sullivan PF, Chess A, Purcell SM, Shinobu LA, Mangravite LM, Toyoshiba H, Gur RE, Hahn CG, Lewis DA, Haroutunian V, Peters MA, Lipska BK, Buxbaum JD, Schadt EE, Hirai K, Roeder K, Brennand KJ, Katsanis N, Domenici E, Devlin B, Sklar P.(2016) Gene expression elucidates functional impact of polygenic risk for schizophrenia.Nature Neuroscience. 19(11):1442-1453
6.Xie H, Li X, Peng J, Chen Q, Gao Z, Song X, Li W, Xiao J, Li C, Zhang T, Gusella JF, Zhong J, Chen X.(2017) A complex intragenic rearrangement of ERCC8 in Chinese siblings with Cockayne syndrome.Sci Rep. 2017 Mar 23;7:44271
7.Zhang L, Wang J, Zhang C, Li D, Carvalho CMB, Ji H, Xiao J, Wu Y, Zhou W, Wang H, Jin L, Luo Y, Wu X, Lupski JR, Zhang F, Jiang Y. (2017) Efficient CNV breakpoint analysis reveals unexpected structural complexity and correlation of dosage-sensitive genes with clinical severity in genomic disorders.Hum Mol Genet. 2017 May 15;26(10):1927-1941
8.Wang C, Xu CX, Alippe Y, Qu C, Xiao J, Schipani E, Civitelli R, Abu-Amer Y, Mbalaviele G. (2017) Chronic inflammation triggered by the NLRP3 inflammasome in myeloid cells promotes growth plate dysplasia by mesenchymal cells.Sci Rep. 2017 Jul 7;7(1):4880
9.Alippe Y, Wang C, Ricci B, Xiao J, Qu C, Zou W, Novack DV, Abu-Amer Y, Civitelli R, Mbalaviele G. (2017) Bone matrix components activate the NLRP3 inflammasome and promote osteoclast differentiation.Sci Rep. 2017 Jul 26;7(1):6630
10.Hall G, Lane BM, Khan K, Pediaditakis I, Xiao J, Wu G, Wang L, Kovalik ME, Chryst-Stangl M, Davis EE, Spurney RF, Gbadegesin RA. (2018) The Human FSGS-Causing ANLN R431C Mutation Induces Dysregulated PI3K/AKT/mTOR/Rac1 Signaling in Podocytes. J Am Soc Nephrol. 2018 Aug 29; (8):2110-2122.
11.Jin L, Wan W, Wang L, Wang C, Xiao J, Zhang F, Zhao J, Wang J, Zhan C, Zhong C. (2018) Elevated microRNA-520d-5p in the serum of patients with Parkinson's disease, possibly through regulation of cereloplasmin expression.Neurosci Lett. 2018 Nov 20;687:88-93
12.Xiao J*, Wang C*, Yao JC, Alippe Y, Xu C, Kress D, Civitelli R, Abu-Amer Y, Kanneganti TD, Link DC, Mbalaviele G. (2018) Gasdermin D mediates the pathogenesis of neonatal-onset multisystem inflammatory disease in mice.PLoS Biol. 2018 Nov 2;16(11):e3000047.
